Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus
نویسندگان
چکیده
منابع مشابه
Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier.
Protective mucus coatings typically trap and rapidly remove foreign particles from the eyes, gastrointestinal tract, airways, nasopharynx, and female reproductive tract, thereby strongly limiting opportunities for controlled drug delivery at mucosal surfaces. No synthetic drug delivery system composed of biodegradable polymers has been shown to penetrate highly viscoelastic human mucus, such as...
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Mucus is a highly viscoelastic and adhesive substance that protects against infection and injury at nearly all entry points to the body not covered by skin. However, mucus also traps potentially life-saving drugs and nucleic acids delivered by synthetic nanoparticles, including those composed of poly(lactic-co-glycolic acid) (PLGA) and poly(e-caprolactone) (PCL), two FDA-approved polymers commo...
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Reports on drug delivery systems capable of overcoming multiple biological barriers are rare. We introduce a nanoparticle-based drug delivery technology capable of rapidly penetrating both lung tumor tissue and the mucus layer that protects airway tissues from nanoscale objects. Specifically, human ferritin heavy-chain nanocages (FTn) were functionalized with polyethylene glycol (PEG) in a uniq...
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Mucus secretions play an important role in the immune system by immobilizing foreign particles and neutralizing invading pathogens. The protective effect of these slippery linings that coat the eyes, airways, and other organs, however, prevents the effective delivery of therapeutics. Benjamin Tang et al. developed a biodegradable nanoparticle that may be able to penetrate thick mucus layers, in...
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I propose a mechanism by which viruses successfully infect new individuals, despite being immotile particles with no ability for directed movement. Within cells, viral particle movements are directed by motors and elements of the cytoskeleton, but how viruses cross extracellular barriers, like mucus, remains a mystery. I propose that viruses cross these barriers by hitch-hiking on bacteria or s...
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ژورنال
عنوان ژورنال: Biomaterials
سال: 2011
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2011.05.008